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Objectives: The infectivity of bile in patients with hepatitis C
virus (HCV) infection remains to be clarified. The purpose of this
study was to document the detection of HCV-RNA in bile of patients
with HCV infection, Methods: Bile and serum samples were tested for
HCV RNA by a two-step polymerase chain reaction technique in 12
patients with HCV infection, Results: HCV-RNA was detected in the
serum of all 12 patients, whereas 6 of 12 bile samples (50%) tested
positive, Comparison of laboratory data between patients with and
without HCV-RNA in bile demonstrated statistically higher serum
total bilirubin among those with positive bile HCV RNA than those
without, but other clinical and biochemical variables as well as
hepatitis activity scores were comparable between the two groups.
Conclusions: Bile of HCV antibody-positive patients could be
infectious.
Author: YANAGA K, KYUSHU UNIV, FAC MED, DEPT SURG 2, FUKUOKA
81282, JAPAN
Source: AMERICAN JOURNAL OF GASTROENTEROLOGY 1997
OCT;92(10):1927-1928
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