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Total Protein test Protein, total (TP), plasma or serum

Normal Range: 6-8 g/dL
SI Range: 60-80 g/L
Blood tube color: Marbled
Specfics of collection: Avoid prolonged venous stasis during collection.

Physiologic Basis:
The plasma protein concentration is determined by the nutritional state, hepatic function, renal function, and various disease states and hydration. The plasma protein concentration determines colloidal osmotic pressure.

Increased in: Polyclonal or monoclonal gammopathies, marked dehydration. Drugs: anabolic steroids, androgens, corticosteroids, epinephrine.

Decreased in: Protein-losing gastroenteropathies, acute burns, nephrotic syndrome, severe dietary protein deficiency, chronic liver disease, malabsorption syndrome, agammaglobulinemia.

The serum total protein consists primarily of albumin and globulin. Hypoproteinemia usually means hypoalbuminemia, since albumin is the major serum protein. Globulin is calculated as total protein minus albumin. Source: Nicoll D, S. J. McPhee, T. M. Chou, W. M. Detmer. Pocket Guide to Diagnostic Tests. Appleton & Lange, 1996.

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