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TITLE: Correlation Between Relative Number Of Circulating
Low-Density Hepatitis C Virus Particles And Disease Activity In
Patients With Chronic Hepatitis C
Hepatitis C virus (HCV) circulates as particles having differing
buoyant densities. Changes in the relative proportions of virus
particles of different densities were examined in 19 patients with
chronic hepatitis C: 6 without (group A) and 13 with (group B)
abnormal serum alanine aminotransferase (ALT) levels, High-and low-
density virus particles were separated by differential flotation
centrifugation, The numbers of high-density particles consistently
exceeded that of low-density particles in all patients in group A,
whereas the titers of both types of particles were the same at
least once in 7 of 10 patients sampled at two time points in group
B, The ALT level significantly increased less than 2 months later
(P less than 0.05) when the titers of both types of particles were
the same in patients in group B. Thus, we found a correlation
between the relative numbers of circulating low-density HCV
particles and disease activity in chronic hepatitis C patients.
AUTHOR: HINO K, YAMAGUCHI UNIV, SCH MED, DEPT INTERNAL MED 1,
1144 KOGUSHI YAMAGUCHI 755, JAPAN
SOURCE: DIGESTIVE DISEASES AND SCIENCES 1997
DEC;42(12):2476-2481
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