|
Home
What is
Hepatitis
How is it
Transmitted
Long Term
Prognosis
Complications of
HCV
Liver
Biopsy
Treatment Info
(Interferon, Herbal, etc)
Lab Tests (PCR,
Genotype,etc.)
Nutrition
& Alternative Info
Patient
Information (Support Groups, Doctor Listing,
etc)
Related
Webpages
Transplant
Info
Site
Search
HCV
Webrings
My
guestbookbook
Site
Awards
FAQ &
Disclaimers
|
TITLE: Assessment of spontaneous fluctuations of viral load in
untreated patients with chronic hepatitis C by two standardized
quantitation methods: branched DNA and Amplicor Monitor.
Quantitation of hepatitis C virus (HCV) RNA in serum has been
used to predict and monitor the efficacy of interferon therapy in
chronic HCV infection. We prospectively studied the fluctuation of
viremia by a longitudinal follow-up of HCV RNA levels for 2 months
in six untreated patients. Spontaneous fluctuations of HCV RNA
ranged from 2.8- to 5.7-fold with branched DNA assay and from 2.9-
to 5.6-fold with Monitor. These large spontaneous fluctuations (up
to 0.75 log), observed daily, weekly, and monthly, raise doubt
about the clinical value of a single assessment of pretherapeutic
viremia.
AUTHOR: Halfon P, Bourliere M, Halimi G, Khiri H, Bertezene
P, Portal I, Botta-Fridlund D, Gauthier AP, Jullien M, Feryn JM,
Gerolami V, Cartouzou G, Alphabio Laboratory, Department of
Biochemistry, Hopital de la Conception, Marseille, France.
alphabio@wanadoo.fr
SOURCE: J Clin Microbiol 1998 Jul;36(7):2073-2075
Home | What is HCV | Transmission |
Future |
Complications |
Biopsy |
Treatment
| Lab |
Nutrition |
Patient |
Links | Transplant |
Webrings |
guestbookbook |
Awards |
FAQ
|
|