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Virus titre and histological inflammation activity in chronic
hepatitis C
(Title Abreviation: Schweiz Med Wochenschr Suppl)
Abstract: We determine the correlation between viremia in serum
specimens, transaminase activity (ALT and AST) and histological
grading in 37 patients with chronic hepatitis C. In addition we
compared two PCR methods for hepatitis C virus (HCV)-RNA in serum
specimens. For the histological grading we used a modified Knodell
score. For detection and quantification we measured the viremia
(HCV-RNA titer) with a standardized "nested primer" PCR (end-point
dilution method) and the commercially available Amplicor HCV
Monitor. The mean HCV-RNA and AST level was significantly higher in
patients with a histologically active inflammation. In the
individual patient we could not conclude from the titer of HCV-RNA
on the histologic grading because of the wide range of the results.
We did not find a significant difference in ALT in patients having
varying histological gradings. HCV-RNA titer and transaminases (ALT
and AST) did not correlate significantly. The HCV-RNA titer was
significantly marked in older patients (above 40 years) and
patients having sporadic hepatitis than in younger patients and
patients with chronic hepatitis after drug abuse. The "nested
primer" PCR (end-point dilution method) was more sensitive for
detection of HCV-RNA in serum specimens than Amplicor HCV Monitor.
The lack of HCV-RNA with Amplicor HCV Monitor in 12 of 37 patients
(32%) did not rule out viremia. We conclude that in patients with a
chronic hepatitis C marked viremia points to a histologically
active inflammation. In the individual patient we could not
conclude from the titer of HCV-RNA on the histological grading.
Because of the lower sensitivity of Amplicor HCV Monitor it is
necessary to confirm negative results with a "nested primer"
PCR.
Author: Bernardi M; Glauser A; Kupferschmidt H; Havelka J;
Zaugg P; Joller-Jemelka HI; Schwery S; Schmid M; BDuhler H;
Date of Pub: 1996 Pagination: 30S-35
Abstract By: Author
Address: Medizinische Klinik, Stadtspital Waid, ZDurich
. Transliterated/Vernacular Title: Virustiter und histologische
EntzDundungsaktivitDat bei chronischer Hepatitis C.
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