Hepatitis C Genotypes: Current Trends and Future
Author: Zein NN; Persing DH
Address: Division of Gastroenterology and Internal Medicine, Mayo
Clinic Rochester, Minnesota 55905, USA.
Source: Mayo Clin Proc, 71: 5, 1996 May, 458-62
To review the geographic distribution and current understanding of
hepatitis C virus (HCV) genotypes in regard to liver disease
activity and response to treatment.
MATERIAL AND METHODS:
We review the relevant medical literature and discuss our recent
findings relative to chronic HCV infection and the importance of
HCV genotypes 1a and 1b are the most commonly found genotypes in
patients with chronic HCV in the United States. Infection with HCV
genotype 1b may be associated with more severe liver disease and
may have a higher risk for the development of hepatocellular
carcinoma. HCV genotype 2b seemed to be the most sensitive and HCV
genotype 1b was the least sensitive to interferon therapy.
The identification of the infectious HCV genotype may be beneficial
in clinical settings and may assist in the selection of patients
who would benefit from interferon treatment.
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