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Aims/Material: Hepatitis C virus (HCV) genotyping was performed in
213 anti-HCV-positive patients with chronic liver disease ranging
from minimal histological changes to hepatocellular carcinoma, One
hundred and twenty-two patients had non-cirrhotic chronic active or
persistent hepatitis (including 29 who were asymptomatic with
persistently normal ALT levels) (chronic liver disease group), The
other 91 had hepatocellular carcinoma and, in all but three cases,
cirrhosis (hepatocellular carcinoma group),
Results: The overall prevalence of HCV variants was: 54.9% type
1b, 37.8% type 2, 2.5% type 1a, 2.0% type 3a, 2.0% type 4a. The
genotype distribution showed no relation to the stage (chronic
liver disease vs, hepatocellular carcinoma) or severity (chronic
active vs, chronic persistent hepatitis) of the liver disease, or
to the duration of the disease (<10 years vs, >10 years),
Within the hepatocellular carcinoma group, the duration of type-lb
disease was similar to that of type-2 infections, Ages at the time
of infection and genotype were both independently associated with
progression to cirrhosis and hepatocellular carcinoma, but
multivariate analysis revealed that the effect of age was much
stronger than that of genotype Ib.
Conclusions: The predominance of HCV type Ib in this study
reflects the higher frequency of this variant in our area, Our
findings indicate that infections caused by each HCV genotype are
capable of progressing to hepatocellular carcinoma.
AUTHOR: MANGIA A, HOSP CASA SOLLIEVO SOFFERENZA, IRCCS, DIV
GASTROENTEROL, I-71013 SAN GIOVANNI ROTO, ITALY
SOURCE: JOURNAL OF HEPATOLOGY 1997 JUN;26(6):1173-1178
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