Title: Hepatitis C Virus (Hcv) Genotypes In Spanish Patients
With Hcv Infection - Relationship Between Hcv Genotype 1b,
Cirrhosis And Hepatocellular Carcinoma
Background/Aims: The influence of the infecting virus genotype
on the progression of the underlying liver disease in patients with
chronic hepatitis C virus (HCV) infection remains controversial,
The aim of this study was to investigate the prevalence of HCV
genotypes in Spanish patients with chronic HCV infection and to
elucidate the relationship between the infecting genotype and the
severity of the disease.
Methods: A cross-sectional, retrospective analysis of frequency
distribution of HCV genotypes was carried out in 414 Spanish
patients with chronic HCV infection, including 243 patients with
asymptomatic or minimally symptomatic chronic hepatitis, 112
patients with cirrhosis and hepatocellular carcinoma and 59
patients with decompensated cirrhosis, HCV genotype was determined
by restriction fragment length polymorphisms of the 5' non-coding
region.
Results: Infection with HCV genotype Ib was found in 72% of
patients with chronic hepatitis and in more than 90% of
patients,vith cirrhosis, with or without hepatocellular carcinoma,
Older age, infection with genotype Ib and absence of overt
parenteral exposure as a possible source of infection mere
associated with cirrhosis and hepatocellular carcinoma by
univariate analysis and this association was confirmed by
regression analysis.
Conclusions: HCV genotype Ib is associated with advanced liver
disease in our geographical area, However, this mag be related to a
cohort-effect caused by over-representation of genotype Ib in older
patients with more advanced disease, because, in our country, this
HCV genotype appeared earlier in time and is therefore associated
with more prolonged periods of infection.
AUTHOR: JMS TAPIAS, UNIV BARCELONA, LIVER UNIT, HOSP CLIN,
VILLARROEL 170 E-08036 BARCELONA, CATALONIA
SOURCE: JOURNAL OF HEPATOLOGY 1997 DEC;27(6):959-965
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