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Title: The Genotype Of The Hepatitis C Virus In Patients With
Hcv-Related B-Cell Non-Hodgkins-Lymphoma
Increasing evidence suggests that the hepatitis C virus (HCV)
might be involved in the pathogenesis of B cell non-Hodgkin's
lymphomas (NHL). Since several HCV genotypes are currently
identifiable and might be involved in the pathogenesis of different
diseases (with different severity and responsiveness to therapy),
the aim of our study was to assess the prevalence of viral
genotypes in a group of patients with HCV-related NHL. Among 470
consecutive patients, 42 HCV Ab-positive cases were identified. HCV
RNA could be detected by reverse transcriptase-polymerase chain
reaction and genotyping performed in 31 of these cases. As compared
to our control group (211 healthy blood donors and patients with
chronic liver disease), a striking high prevalence of genotype 2ac
was detected among B cell NHL (48.4 vs 9.0%), with a relative risk
of infection of 5.37 (P less than 0.0001). No major differences
were observed in the distribution of NHL histotypes and in the
clinical features among patients with genotype 1b (the other most
frequent genotype) or 2ac, a part from a trend towards a higher
percentage of liver disease and a lower likelihood of response to
interferon for patients with genotype 1b. The same high prevalence
of genotype 2ac has been recently reported in patients with mixed
cryoglobulinemia (MC), monoclonal gammopathies, B cell NHL
complicating MC and autoimmune hepatitis. All these data taken
together suggest that genotype 2ac might be involved in the
pathogenesis of lymphoproliferative and autoimmune disorders.
AUTHOR: SILVESTRI F, UNIV HOSP, DIV HEMATOL I-33100 UDINE,
ITALY
SOURCE: LEUKEMIA 1997 DEC;11(12):2157-2161
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