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Kobayashi, M., Tanaka, E., Sodeyama, T., Urushihara, A.,
Matsumoto, A., and Kiyosawa, K. 1996.
The natural course of chronic hepatitis C: a comparison between
patients with genotypes 1 and 2 hepatitis C viruses. Hepatology.
23:695-699.
Several studies have demonstrated that different hepatitis C
virus (HCV) genotypes cause different severity of liver disease. In
this study, the authors studied 140 patients in Japan. They found
that 96 patients were infected with genotype 1b, 4 with either
genotype 1a or 1b and 36 with either genotype 2a or 2b (genotype
could not be determined in 4 patients). Patients infected with
genotype 1 had higher circulating levels of HCV RNA than those
infected with genotype 2. Deterioration in the grade and stage of
liver histology, determined by follow-up biopsy 5 to 20 years after
the initial biopsy, was seen more frequently in patients infected
with genotype 1 (68.0% grade, 63.0% stage) than in those infected
with genotype 2 (41.7% grade, 38.9% stage). These results suggest,
as have previous studies, that more severe progression of chronic
hepatitis C is seen in patients infected with genotype 1b than with
genotype 2.
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