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J Hepatol 1998 Aug;29(2):207-213
Association between HLA class II genotype and spontaneous clearance
of hepatitis C viraemia.
Cramp ME, Carucci P, Underhill J, Naoumov NV, Williams R, Donaldson
PT Institute of Liver Studies, King's College Hospital, London, UK.
[Medline record in process]
BACKGROUND/AIMS: Hepatitis C virus (HCV) infection becomes
chronic in most cases, with only 10-20% of those infected not
developing persistent viraemia. The immune response to HCV may be
an important determinant of disease resolution and can be
influenced by a number of host factors. The aim of this study was
to assess the role of host HLA class II type in influencing viral
clearance or susceptibility to chronic HCV infection.
METHODS: We have compared the distribution of HLA DRB1, DQA1 and
DQB1 alleles in 49 patients with spontaneous clearance of HCV
infection (HCV antibody positive but persistently HCV RNA
negative), with 55 chronically infected patients and 134 racially
matched controls. RESULTS: Three alleles were found significantly
more frequently in patients with spontaneous viral clearance
compared to those with chronic infection-DRB1*04 (pc=0.0022, odds
ratio OR=4.52), DQA1*03 (pc=0.0012, OR=4.69) and DQB1*0301
(pc=0.0078, OR=5.09). DQB1*0302 was found at reduced frequency in
all HCV-antibody-positive patients compared to controls
(pc=0.0063).
CONCLUSIONS: DRB1*04, DQA1*03 and DQB1*0301 are associated with
spontaneous clearance of HCV viraemia, with the primary association
likely to be with DQB1*0301 and the associations with DRB1*04 and
DQA1*03 being due to linkage. In addition, DQB1*0302 is associated
with protection from HCV infection. These findings suggest that
host HLA class II genotype is an important factor in determining
the outcome of infection with hepatitis C virus.
PMID: 9722201, UI: 98387656
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