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TITLE: Chronic hepatitis C in children: a clinical
and immunohistochemical comparative study with adult patients.
Limited information is available regarding the characteristics
of the hepatitis C virus (HCV) infection in children. We compared
the epidemiological background along with the virological and
histological features as well as the intrahepatic immunologic
phenotype of both children and adults with chronic hepatitis C
(CHC). Serum samples of 24 pediatric and 32 adult patients were
drawn for alanine transaminase (ALT) levels, HCV-typing, and viral
load. The histological diagnosis and a semiquantitative
immunohistochemical assessment were performed in all patients. The
majority of children (62%) had been transfused and the mean
duration of viral infection in these cases was 11 +/- 4 years,
being similar in adults (11 +/- 9 years, not significant). Although
genotype distribution was similar, viral load was lower in children
than in adults. The mildest histological forms of chronic hepatitis
along with a weak intrahepatic immunological phenotype were
significantly more frequent among children than adult patients. In
conclusion, in children with CHC, perinatal blood transfusion was
the most frequent source of viral infection and the liver disease
was characterized by both low ALT level and viral load, as well as
the mildest histological and immunohistochemical forms of chronic
hepatitis.
AUTHOR: Garcia-Monzon C, Jara P, Fernandez-Bermejo M, Hierro
L, Frauca E,Camarena C, Diaz C, De la Vega A, Larrauri J,
Garcia-Iglesias C, Borque MJ,Sanz P, Garcia-Buey L,
Moreno-Monteagudo JA, Moreno-Otero R Liver Unit, Hospital de la
Princesa, Madrid, Spain.
garciamonzon@hotmail.com; SOURCE: Hepatology 1998
Dec;28(6):1696-701
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