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TITLE: Hepatitis C in children after transfusion:
assessment by look-back studies.
Look-back studies to identify paediatric patients with
post-transfusion hepatitis C have been conducted at several
tertiary-care hospitals in Canada. A general look-back study was
conducted at the Hospital for Sick Children in Toronto for the time
period December 1985 to May 1990. All patients transfused at the
Hospital for Sick Children during this time period were identified
from hospital Blood Bank records. Letters of notification were sent
by registered mail to all recipients excluding those known to have
died. In the letter anti-HCV testing was recommended. Letters were
mailed to 6332 transfusion recipients; 4496 letters were delivered.
Of these 146 anti-HCV-positive transfusion recipients (92 pts less
than 18 yrs old; 54 pts greater than 18 yrs old) were identified.
Sixty-four of these patients were definitely transfused only during
this time period. Assuming that all notified patients were tested,
the minimum prevalence of new infection in this time period was
1.4%. When possible, identified patients were tested for presence
of HCV RNA in the serum by RT-PCR. The proportion of patients
anti-HCV positive but HCV RNA negative on one or more occasions was
similar in both whole cohort and subset: approximately one-third.
These data suggest that chronic hepatitis C may be less likely to
develop after transfusion in children than in adults.
AUTHOR: Roberts EA, King SM, Fearon M, McGee N Division of
Gastroenterology and Nutrition, Hospital for Sick Children,
Toronto, Ontario, Canada.; SOURCE: Acta Gastroenterol Belg 1998
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