A 34-year-old woman with chronic hepatitis C received
interferon- alpha (IFN-alpha) therapy. Her thyroid function was
normal and thyroid autoantibodies were negative before treatment,
Four months after the beginning of the therapy she presented a
clinical course of thyroiditis with a transient thyrotoxicosis. The
diagnosis of subacute thyroiditis was confirmed by laboratory,
ultrasonography, radioiodine scanning and fine needle aspiration
findings. Thyroid autoantibodies were persisting negative. She
suspended IFN-alpha therapy and she started non steroidal
anti-inflammatory agents and beta-blockers. Latent hypothyroidism
subsequently developed, but L- thyroxine therapy resulted in a
rapid normalization of thyroid function tests. (C) 1997, Editrice
Kurtis.
Author: FALASCHI P, UNIV ROMA LA SAPIENZA,
CATTEDRA CLIN MED 1, V POLICLIN 155, I-00161 ROME, ITALY Source:
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 1997
JAN;20(1):24-28
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