HCV Associated Nephropathy

We analyzed the clinicopathological features and therapy in 19 patients with kidney disease accompanied by hepatitis C viral infection, including 12 patients with mesangial proliferative glomerulonephritis (including eight with IgA nephropathy), six with membranoproliferative glomerulonephritis (MPGN), and one with membranous nephropathy. Persistent hematuria and/or proteinuria (10 patients) was the most common finding, followed by nephrotic syndrome (8 patients). Cryoglobulinemia was detected in six of 19 patients examined (four of six patients with MPGN), Analysis of hepatitis C virus (HCV)-RNA genotype in 13 patients revealed that nine of them had type II genotype. All four patients with MPGN, who had serum positive for HCV-RNA, had type II genotype. Five patients were treated with interferon-alpha (IFN-alpha) without a demonstrable effect on renal impairment, whereas five of 11 patients treated with steroids showed improvement of the renal impairment. During the course of steroid therapy, the serum titer of HCV-RNA decreased in 5 of 7 patients. These observations suggest that HCV infection may be associated with several forms of glomerulonephritis. Type II HCV-RNA may have a strong association with MPGN in Japan. Steroid therapy is not contraindicated in patients with HCV-associated nephropathy if they are resistant to IFN-alpha treatment.

INTERNAL MEDICINE 1996 JUL;35(7):529-533 Authors: KOMATSUDA A, IMAI H, WAKUI H, HAMAI K, OHTANI H, KODAMA T, OYAMA Y, MIURA AB, NAKAMOTO Y

Advertisement
Hepatitis C Primer Home

What is Hepatitis How is Hepatitis Transmitted

Long-term Prognosis

Complications of HCV Liver Biopsy Treatment Info (Interferon, Herbal, etc) Lab Tests (PCR, Genotype,etc.) Nutrition & Alternative Info

Patient Information (Support Groups, Doctor Listing, etc) Related Webpages Transplant Info Site Search HCV Webrings Guestbook FAQ & Disclaimers

FREE Educational Webinar: What You Need to Know About HCV
If you or a family member was recently diagnosed, this free webinar from the American Liver Foundation and the Chronic Liver Disease Foundation could be the educational resource you've been looking for.

FREE WEBINAR Diagnosing and Treating HE: A Physician’s Perspective
Register for this free webinar if you'd like a better grasp of this complicated condition or want a clearer understanding about a specific HE-related issue.

Gilead Gets Approved for Accelerated Assessment of Hep C Drug
The European Medicines Agency will conduct a full assessment of Gilead Science's Hepatitis C therapy.

More Hep C articles ...