Leucocytoclastic vasculitis associated with hepatitis C virus antibodiesThe actiopathogenesis of leucocytoclastic vasculitis is still unknown, but recently hepatitis C virus (HCV) has been suggested as trigger of autoimmunity. We report a case of a 26-yr-old patient with purpura due to leucocytoclastic vasculitis associated with hepatitis C virus infection. Laboratory findings showed AST, ALT, gamma GT within normal limits, positive antibodies to HCV (IIF and Riba II) and polymerase chain reaction for HCV RNA. Anti-nuclear antibodies, IgG and IgM anti-cardiolipin antibodies, anti-platelet antibodies and anti-neurophil cytoplasmic antibodies with perinuclear pattern were also present. A skin biopsy specimen of a purpuric lesion showed leucocytoclastic vasculitis with small vessel thrombosis and perivascular deposition of IgM and fibrinogen on immunofluorescence study. This case shows a role of HCV in leucocytoclastic vasculitis; it is possible that this HCV can induce autoimmunity independently of cryoglobulins and liver involvement. Author: Manna R, Todaro L, Latteri M, Gambassi G, Massi G, Grillo MR, Romito A, Caputo S, Gasbarrini GB, Department of Internal Medicine, Catholic University of Sacred Heart, Rome, Italy. Source: Br J Rheumatol 36 (1): 124-125 (1997) |
Advertisement
|
What is Hepatitis How is Hepatitis Transmitted
Complications of HCV Liver Biopsy Treatment Info (Interferon, Herbal, etc) Lab Tests (PCR, Genotype,etc.) Nutrition & Alternative Info
Patient Information (Support Groups, Doctor Listing, etc) Related Webpages Transplant Info Site Search HCV Webrings Guestbook FAQ & Disclaimers
15 Tips for Managing Interferon-Ribavirin Side Effects New Mexico Offers Free Hepatitis C Hotline Highly Effective Against HCV Genotype 1 |