Title: DISTAL GANGRENE IN CRYOGLOBULINEMIA ASSOCIATED WITH HEPATITIS C VIRUS AND ANTICARDIOLIPIN ANTIBODIES

We report the case of a 63-year old women with toe gangrene, peripheral polyneuropathy, polyarthritis, histologically proven necrotizing vasculitis, in association with type III mixed cryoglobulinemia and hepatitis C virus (HCV) infection. Raised anticardiolipin antibodies (aCL) were found, without beta 2- glycoprotein I. HCV infection is associated with mixed cryoglobulinemia which can cause a vasculitis affecting various organs. The pathogenesis of production and clinical significance of aCL could be associated in this case with HCV infection.

Author: JACQ F, HOP BROUSSAIS, SERV MED INTERNE, 96 RUE DIDOT, F-75674 PARIS 14, FRANCE; Source: REVUE DE MEDECINE INTERNE 1997 ;18(4):324-327

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