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Suicide associated with alfa-interferon therapy for chronic
viral hepatitis
Author: Janssen HL; Brouwer JT; van der Mast RC; Schalm SW;
Source: Journal of Hepatology Date of Pub: 1994 Aug Suppl: 2 Vol:
21 Pagination: 241-3
Abstract: We report on two attempted suicides and one successful
suicide during or shortly after alfa-interferon therapy for chronic
viral hepatitis. While on therapy, all three patients developed a
psychiatric disorder leading to their suicidal behavior. In a
survey of 15 European hospitals, three cases of attempted and two
of successful suicide during alfa-interferon therapy for chronic
viral hepatitis, were additionally reported. None of the patients
had a psychiatric history. Alfa-interferon is known to lead to
neuropsychiatric symptoms, and our observations strongly suggest
that these mental disorders could lead to suicidal behavior.
Therefore it is important that physicians, patients and their
families are informed about the potential risk of the emotional and
psychiatric disturbances that can occur during alfa-interferon
therapy.
Abstract By: Author Address: Department of Internal Medicine
II (Section Hepatology), University Hospital Dijkzigt, Rotterdam,
The Netherlands.
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