|
Home
What is
Hepatitis
How is it
Transmitted
Long Term
Prognosis
Complications of
HCV
Liver
Biopsy
Treatment Info
(Interferon, Herbal, etc)
Lab Tests (PCR,
Genotype,etc.)
Nutrition
& Alternative Info
Patient
Information (Support Groups, Doctor Listing,
etc)
Related
Webpages
Transplant
Info
Site
Search
HCV
Webrings
My
guestbookbook
Site
Awards
FAQ &
Disclaimers
|
Short-Term versus sustained response to Inteferon therapy -
effect on histology
In order to evaluate the histological treatment response in
patients with chronic hepatitis C virus (HCV) infection, different
histological scoring systems have been developed. The scoring
systems provide means of statistically comparing histopathological
parameters in serial liver biopsies and have thus become important
requirements of therapeutic trials. Patients with biochemical and
virological responses to interferon (IFN) also improve
histologically during treatment. However, after treatment
cessation, many patients will have a biochemical/virological
relapse. These short-term responders also relapse histologically,
thus limiting the long-term benefit of a single treatment course,
although, repeated courses of IFN in short-term responders may
retard histological deterioration. In contrast, sustained
biochemical/virological responders seem to have a durable
histological response with a continuous and gradual improvement of
all necroinflammatory parameters and fibrosis posttreatment.
Author: REICHARD O, KAROLINSKA INST, DANDERYD HOSP, DEPT
INFECT DIS, S-18288 DANDERYD, SWEDEN
Source: DIGESTIVE DISEASES AND SCIENCES 1996 DEC;41(12):S 109-S
114
Home | What is HCV | Transmission |
Future |
Complications |
Biopsy |
Treatment
| Lab |
Nutrition |
Patient |
Links | Transplant |
Webrings |
guestbookbook |
Awards |
FAQ
|
|