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LATE REACTIVATION OF CHRONIC HEPATITIS C AFTER LONG TERM
SUSTAINED RESPONSE TO INTERFERON THERAPY.
Author: L Corbosiero, L Tallarico, E Di Vaia*. Divisione
Medicina Interna ed Epatologia, Ospedale CTO, ASL Napoli 1, Italy
(Primario A. Bizzarri) and *Psichiatria ASL Napoli 1.
We proposed one year long recombinant alpha 2b Interferon
therapy (from November 1989 to November 1990) to 50 patients with
chronic active hepatitis (CAH), HCV correlate. The starting dose
was 6 MU tiw for six months; we went on with 3 MU tiw for three
months, then 1.5 MU tiw for three months. We also proposed one year
long lymphoblastoid Interferon therapy (from June 1992 to June
1993) to 50 patients with the same disease. We used the same
dosage. We regularly checked the patients: in both cases we had a
22 per cent of sustained response. Five years after the end of the
recombinant alpha 2b Interferon therapy we had a 18,18 per cent of
CAH reactivation in those patients who showed a sustained response.
Almost three years after the end of the lymphoblastoid Interferon
therapy we had a 27,27 per cent of CAH reactivation in those
patients who showed a sustained response. In conclusion, three or
more years after the end of a one year long Interferon therapy a
percentage between 16 and 18% of patients shows a sustained
response.
Source: American Association for the Study of Liver Diseases
- 1996 Annual Meeting
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