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WESTPORT, Feb 19, 1996 (Reuters)

While interferon-alpha 2B is known to be effective in some patients with chronic hepatitis C viral infection, few patients have a sustained response when the drug is given in standard doses. That prompted Dr. Herbert L. Bonkovsky and colleagues at the University of Massachusetts at Worcester to test whether higher doses of the drug would be effective.

Twenty-four patients who had failed to respond to standard interferon therapy or had relapsed after an initially successful course of interferon therapy were randomized to receive higher doses, either 15 million units or 22.5 to 30 million units weekly for 24 weeks. Only one patient had a sustained response, leading the researchers to conclude that high-dose therapy is seldom beneficial and causes more side effects, as well.

Digest Dis Sci 1996;41:149-153.

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