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Flashback Phenomenon During Interferon Treatment
Title:
A patient with chronic hepatitis C and a history of abuse of
analeptic drugs, who showed hallucination and delusion with
interferon administration.
Author: Muraoka H; Sanefuji T; Keida R; Tsuji R; Abe H;
Uchimura Y; Sata M; Tanikawa K; Nose I; Uchimura N; Nakazawa Y;
Source: Kurume Medical Journal
Date of Pub: 1996 Issue: 1 Volume: 43 Pagination: 73-7
Abstract:
We experienced a case of chronic hepatitis type C accompanied with
hallucination and delusion induced by interferon (IFN) therapy
positive. The case was a 47-year-old male, whose laboratory data
showed positive for anti-Hepatitis C Virus (HCV) and elevated
transaminase level. He was treated with 6 MU/day of natural-type
IFN-alpha (HLBI). Sleeplessness and delusions of persecution
developed about 2 months after the start of IFN therapy. The
interview of the psychiatrist disclosed that the patient had a
history of addiction to drugs, and these psychiatric symptoms were
diagnosed as being of "the flashback phenomenon." These side
effects were improved after the administration of psychotropics and
it was suggested that we had to take care of the development of
flashback phenomenon during the treatment of IFN in cases of
chronic hepatitis with a history of addiction to drugs.
Abstract By: Author
Address: Department of Internal Medicine, Kumamoto Central
Hospital, Japan.
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