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URSODEOXYCHOLIC ACID IN THE TREATMENT OF LIVER DISEASES
Ursodeoxycholic acid is a dihydroxy bile acid with a rapidly
expanding spectrum of usage in acute and chronic liver diseases.
The various mechanisms of action of this hydrophilic bile acid
include direct cytoprotection, detergent action on dysfunctional
microtubules, immunomodulation and induction of hypercholeresis.
Its efficacy in primary biliary cirrhosis and primary sclerosing
cholangitis as an adjunct to medical therapy has been well
established. Newer indications include its use in the management of
chronic hepatitis, cirrhosis, post liver transplant rejection,
graft -versus-host disease and acute viral hepatitis, where it not
only relieves symptoms of cholestasis but also arrests ongoing
hepatocyte necrosis.
Author: RK TANDON, ALL INDIA INST MED SCI, DEPT
GASTROENTEROL, NEW DELHI 110029, INDIA
Source: POSTGRADUATE MEDICAL JOURNAL 1997 FEB;73(856):75-80
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