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UCDA descreases the LFTs of chronic liver disease patients
treated with SNMC
The effects of ursodeoxycholic acid (UDCA) on the liver function
test values were investigated in patients with chronic hepatitis
(CH) and liver cirrhosis (LC) in whom treatment with glycyrrhizin
(SNMC) for more than 6 months had failed to improve serum
transaminase levels. Twenty-six patients treated with Stronger neo
minophagen C (SNMC), 60 ml, i.v., three times/week) for more than 6
months were given UDCA (Urso, 600 mg/day) in addition (SNMC + UDCA
group) and 22 patients were given UDCA (Urso, 600 mg/day) alone
(UDCA group). The mean AST, ALT, gamma-GTP and total bile acid
(TEA) values during the 3 months before UDCA treatment and the 3
months after the start of UDCA treatment were compared in each
case. The results showed that AST, ALT and gamma-GTP were improved
by 28, 34 and 46%, respectively in the 24 patients with CH, type C
in the SNMC f UDCA group, and 27, 30 and 39%, respectively in the
14 patients with CH, type C in the UDCA group. UDCA was also
effective in improving AST and ALT in the patients in the SNMC +
UDCA group who were resistant to interferon therapy. The
percentages of improvement in AST, ALT and gamma-GTP in the 10 LC
patients were lower than in the CH patients in both SNMC f UDCA and
UDCA group. In conclusion, UDCA is useful in decreasing the serum
transaminase levels of patients with CH, even when they are being
treated with SNMC. (C) 1996 Elsevier Science Ireland Ltd.
Author: MITSUYOSHI H, KYOTO PREFECTURAL UNIV MED, DEPT
INTERNAL MED 3, KAMIGYO KU, KYOTO 602, JAPAN
Source: INTERNATIONAL HEPATOLOGY COMMUNICATIONS 1996
DEC;6(2):85-91
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